Portland Timbers3–1Club Tijuana
Cruz Azul1–2Chicago Fire
Club America1–1Austin
New York City FC1–2Necaxa
Philadelphia Union0–2Santos Laguna
Seattle Sounders1–2Guadalajara Chivas
Los Angeles FC1–1Club Queretaro
San Diego3–2Puebla
Toluca3–1FC Dallas
Monterrey2–1Nashville SC
Inter Miami2–3Leon
Orlando City SC2–2Atletico San Luis
Tigres UANL1–1Vancouver Whitecaps
Real Salt Lake3–0FC Juarez
Minnesota United FC3–1Atlante FC
FC Cincinnati1–2Atlas
Columbus Crew1–1U.N.A.M. - Pumas
Charlotte0–1CF Pachuca
Club America3–1Portland TimbersSan Diego1–0Club Tijuana